Figure 1.

Inflammatory and regulatory functions of myeloid receptors and DAMPs compiled in this review. Upon tissue damage conditions, dead cells release DAMPs (in italic in the chart) that can be recognized by receptors expressed in myeloid cells. This recognition triggers either inflammatory (left oval) or regulatory (right oval) responses. Some of these receptors can work simultaneously (dashed lines) as dying cells do not release isolated DAMPs but a mix of them. Of note, some of these DAMPs such as HMGB1 or SAP130 can trigger both inflammatory and regulatory responses depending on the context.