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. 2020 Oct 6;11(10):828. doi: 10.1038/s41419-020-03020-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Diagram illustrating the molecular cascade characteristic of the oxytosis/ferroptosis cell death program. b Levels of total and oxidized/reduced GSH in MC65 nerve cells after 2 days of Aβ induction (n = 5/group). c Levels of eicosanoids derived from enzymatic (COX, 5-LOX, 12-LOX, 15-LOX) and non-enzymatic oxidation of AA measured at day 2. 13,14-dihydro-15-keto-prostaglandin D₂ (dhk PGD2); 13,14-dihydro-15-keto-prostaglandin F₂ alpha (dhk PGF2a); prostaglandin D₂ (PGD2); prostaglandin E₂ (PGE2); prostaglandin J₂ (PGJ2); tetranor-prostaglandin EM (tetranor-PGEM); tetranor-prostaglandin EM (tetranor-PGFM); 12-hydroxyheptadecatrenoic acid (12-HHTrE); 15-deoxy-delta 12,14-prostaglandins D² (15d PGD2); (5-HETE); tetranor-12-hydroxyeicosatetraenoic acid (tetranor 12-HETE); 5,15-dihydroxyeicosatetraenoic acid (5,15-diHETE); 6R-lipoxin A₄ (6R-LXA4); 6S-lipoxin A₄ (6S-LXA4); 15-hydroxyeicosatetraenoic acid (15-HETE); prostaglandin F₂ alpha VI (5-iso PGF2aVI); 11-hydroxyeicosatetraenoic acid (11-HETE). Unpaired two-tailed t-test (n = 4/group). d Global lipid peroxidation at day 2. Unpaired two-tailed t-test (n = 3–4/group). e Whole cell ROS production at day 2. Unpaired two-tailed t-test (n = 11/group). f Mitochondrial superoxide production day 2. Unpaired two-tailed t-test (n = 3/group). All data are mean ± SD.