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. 2020 Oct 6;11(10):828. doi: 10.1038/s41419-020-03020-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Susceptibility of non-induced and induced MC65 nerve cells to (a) glutamate and (b) RSL3 assessed at day 2 after induction of Aβ. Two-way repeated measures ANOVA and Tukey post hoc corrected t-test (n = 3/group). c Effects of oxytosis/ferroptosis inhibitors in non-induced and induced MC65 nerve cells on day 3. The inhibitors tested included: CMS121 (1 μM), J147 (1 μM), liproxstatin (10 μM), ferrostatin (10 μM), deferiprone (75 μM), deferoxamine (20 μM), NDGA (0.5 μM), LY83583 (1 μM), and CoCl₂ (25 μM). Two-way repeated measures ANOVA and Tukey post hoc corrected t-test (n = 6/group). Effects of oxytosis/ferroptosis inhibitors in HT22 nerve cells exposed to (d) glutamate (10 mM) and (e) RSL3 (100 nM). The oxytosis/ferroptosis inhibitors included: CMS121 (1 μM), J147 (1 μM), liproxstatin (5 μM), ferrostatin (5 μM), deferiprone (75 μM), deferoxamine (50 μM), NDGA (10 μM), LY83583 (0.5 μM), and CoCl₂ (100 μM). Two-way repeated measures ANOVA and Tukey post hoc corrected t-test (n = 6/group). ***P < 0.001. All data are mean ± SD.