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. 2020 Oct 6;6:97. doi: 10.1038/s41420-020-00333-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic diagram of experimental design. PN were intraperitoneally injected within 10 min after weight drop at the T10 level, and then continuously injected daily until 7 days after injury. b Basso, Beattie, and Bresnahan (BBB) limb function scores at different times after spinal cord contusion. c Representative footprints of an animal walking 14 days after SCI. Blue: forepaw print; red: hindpaw print. d Quantitative analysis of the footprint (c) in the two groups. e Gross morphology of spinal sections on day 14 postinjury. The boundary of the traumatic lesion area is indicated by the dashed lines. f Representative Nissl-stained sagittal section of spinal cord on day 14 postinjury. Scale bar, 1000 μm. g Quantitative analysis of lesion volume (f) in the two groups. All data are presented as means ± SEM (n = 5 mice per group). *P < 0.05.