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. 2020 Oct 6;11(10):831. doi: 10.1038/s41419-020-03037-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Growth curves of MCF7 cells stably expressing HA synthase 2 (HAS2) or naïve MCF7 cells treated with BYL719 at increasing concentrations for 4 days. Data are represented as the mean (±SD). *p < 0.05. b AKT/mTOR signaling was evaluated in MCF7/HAS2 cells treated with 1 μM BYL719 with or without an HAS inhibitor (4-methylumbelliferone, 0.2 μM) for 3 days. c AKT/mTOR signaling was evaluated in MCF7/HAS2 cells treated with BYL719 (1 μM), BYL719 (1 μM) plus hyaluronidase (hyal), or the combination of BYL719 and an HAS inhibitor (0.2 μM) for 24 h. d The proliferation of MCF7/HAS2 cells treated with BYL719 (1 μM), BYL719 (1 μM) plus hyaluronidase (hyal), or the combination of BYL719 and an HAS inhibitor (0.2 μM) for 3 days was determined. Each value is the mean (±SD). *p < 0.05 vs. control, n = 5.