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. 2020 Sep 23;11:576347. doi: 10.3389/fimmu.2020.576347

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Copyright © 2020 Chaurasia, Talbot and Summers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depicting the enzymatic pathways involved in cellular ceramide synthesis. CERS, Ceramide synthase; DES, Dihydroceramide desaturase; KDSR, 3-ketodihydrosphinganine reductase; SMS, Sphingomyelin synthase; SMase, Sphingomyelinase.