Figure 6.

Schematic of depot formation affecting induction and persistence of germinal centers. Depot-forming adjuvants sequester antigen at the site of injection. Early after immunization this leads to reduced B cell activation and GC formation in the draining LNs, compared to when antigen is given in an adjuvant which does not form an antigen depot. The slow release of antigen from the depot may help sustain germinal centers to promote a higher magnitude long-term antibody response as illustrated by data adapted from Figure 1 (right panel).