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MI-2 inhibited the growth of T-ALL cells. (A–C) CCRF and MOLT-4 were incubated with increasing concentrations of MI-2 for 24, 48, and 72 h, respectively. Cell viability was quantified using CCK-8 assay and shown as% of the untreated control. (D,E) CCRF and MOLT-4 were cultured in methylcellulose with indicated doses of MI-2 for 12 days. MI-2 significantly decreased the quantity and size of cell colonies. *P < 0.05, **P < 0.01.
