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. 2020 Sep 23;10:558339. doi: 10.3389/fonc.2020.558339

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Copyright © 2020 Wang, Zhang, Xu, Zhang, Pan, Zhong, Zhang, Yin, Yao, Wu, Li, Liu, Xu and Niu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MI-2 impaired leukemia progression in vivo. (A) Kaplan–Meier survival curves for recipient mice transplanted with CCRF leukemic cells are shown. Administration of vehicle or MI-2 (20 mg/kg per day for 20 days) began 2 days after transplantation. (B) Representative photographs of differences in spleen sizes are shown. (C) FACS analysis of the distribution of human CCRF cells in BM, PB, spleen, and liver of mice and stained with anti-human CD45. (D) The percentage of CD45 positive cells was quantified. *P < 0.05.