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. 2020 Sep 23;10:558339. doi: 10.3389/fonc.2020.558339

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Copyright © 2020 Wang, Zhang, Xu, Zhang, Pan, Zhong, Zhang, Yin, Yao, Wu, Li, Liu, Xu and Niu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism for MALT1 inhibition by MI-2. MALT1 is crucial for Notch1-induced NF-κB activation. MI-2 inhibits NF-κB activation by increasing IκBα proteins and inhibiting p65 nucleus translocation.