B. Non-immediate reactions

		Allergic to multiple ICM n = 28	Allergic to a single ICMn = 61	p
Age; median (interquartile range) years		64.5 (49–69.25)	61 (52.35–63)	0.4356
Gender; n (%) female/n (%) male		15 (53.57)/13 (42.85)	30 (49.18)/31 (50.81)	0.7004
Symptoms reported; n (%)	Urticaria MPE	8 (28.57) 20 (71.42)	21 (34.42) 40 (65.57)	0.5842
ICM involved	Iodixanol Iomeprol Iohexol Iobitridol Iopramida Ioxaglate Unkown	8 (28.57) 8 (28.57) 6 (21.42) – – 1 (3.57) 5 (17.85)	19 (27.86) 22 (32.78) 9 (13.11) 2 (3.27) 1 (1.63) – 8 (13.11)	0.8061 0.4874 0.4348 NA NA NA 0.5564
Time interval between ICM administration and reaction onset; n (%)	1–6 h 7–12 h 13–24 h 25–48 h >48 h	– 4 (14.28) 11 (39.28) 10 (35.71) 3 (10.71)	1 (1.63) – 28 (45.9) 27 (44.26) 5 (8.19)	NA NA 0.8795 0.7435 0.6998
No of episodes	1 episode 2 episodes	26 (92.85) 2 (7.14)	49 (80.32) 12 (19.67)	0.1317
Positive results in STs		24/28; 85.71% Iomeprol 16 Iohexol 7 Iodixanol 8 Iobitridol 3 Ioxaglate 3 Iopramida 1	15/61; 24.59% Iomeprol 8 Iodixanol 3 Iobitridol 2 Ioxaglate 1	0.00000006785

A.ICM, iodinated contrast media; MPE, maculopapular exanthema; NA, not applicable.