Table 2.
The incidence and HRs for risk of hypertension associated with PCOS, age and comorbidities.
| Variables | Hypertension (n = 2,505) | Crude HR (95% CI) | Adjusted HR (95% CI) | ||
|---|---|---|---|---|---|
| Event | PY | IR | |||
| PCOS | |||||
| No | 1,715 | 405,264 | 4.23 | 1 (reference) | 1 (reference) |
| Yes | 790 | 100,597 | 7.85 | 1.85 (1.70–2.02)** | 1.62 (1.48–1.76)** |
| Age, years | |||||
| ≤30 | 881 | 316,850 | 2.78 | 1 (reference) | 1 (reference) |
| >30 | 1624 | 189,011 | 8.59 | 3.16 (2.91–3.44)** | 2.88 (2.65–3.13)** |
| Comorbidities | |||||
| Diabetes mellitus | |||||
| No | 2,229 | 495,115 | 4.50 | 1 (reference) | 1 (reference) |
| Yes | 276 | 10,746 | 25.68 | 5.79 (5.11–6.56)** | 3.00 (2.61–3.45)** |
| Hyperlipidemia | |||||
| No | 2,229 | 493,256 | 4.52 | 1 (reference) | 1 (reference) |
| Yes | 276 | 12,604 | 21.90 | 5.06 (4.46–5.73)** | 2.42 (2.11–2.79)** |
| COPD | |||||
| No | 2125 | 450,277 | 4.72 | 1 (reference) | 1 (reference) |
| Yes | 380 | 55,584 | 6.84 | 1.51 (1.35–1.68)** | 1.10 (0.96–1.27) |
| Asthma | |||||
| No | 2338 | 483,376 | 4.84 | 1 (reference) | 1 (reference) |
| Yes | 167 | 22,485 | 7.43 | 1.62 (1.38–1.89)** | 1.27 (1.04–1.56)* |
| CKD | |||||
| No | 2,437 | 500,077 | 4.87 | 1 (reference) | 1 (reference) |
| Yes | 68 | 5,784 | 11.76 | 2.47 (0.94–3.15)** | 1.53 (1.20–1.95)** |
| CAD | |||||
| No | 2,439 | 501,290 | 4.87 | 1 (reference) | 1 (reference) |
| Yes | 66 | 4,571 | 14.44 | 2.96 (2.32–3.78)** | 1.82 (1.42–2.33)** |
| CHF | |||||
| No | 2,496 | 505,274 | 4.94 | 1 (reference) | 1 (reference) |
| Yes | 9 | 587 | 15.33 | 3.21 (1.67–6.18)** | 1.65 (0.85–3.20) |
*
p < 0.05,
**
p < 0.001.
HR adjusted for age, diabetes mellitus, hyperlipidemia, COPD, asthma, CKD, CAD and CHF.
CAD, coronary artery disease; CHF, congestive heart failure; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; IR, incidence rate, per 1,000 person-years; PCOS, polycystic ovarian syndrome; PY, person-years.