TABLE 1.
Exosomal lncRNAs in lung cancer.
| LncRNAs | Exosome function | Origin of exosomes | Sample collection | Recipient cells | References |
| H19 | Promotes gefitinib/erlotinib resistance | HCC827, HCC4006, A549 | Blood, culture medium | Non-small cell lung cancer | (145, 146) |
| GAS5 | Biomarker | NSCLC cells | Blood | / | (77) |
| GAS5 | Promotes tumor angiogenesis | Lung cancer cells | Culture medium | Human umbilical vein endothelial cells | (133) |
| MALAT 1 | Promotes cell proliferation and migration | NSCLC cells | Blood | A549, H1299 | (25) |
| RP11-838N2.4 | Promotes erlotinib resistance | NSCLC cells | Blood | HCC827, HCC4006 | (147) |
| DLX6-AS1 | Biomarker | NSCLC cells | Blood | / | (154) |
| / | Regulate silicosis | Lung tissue of silica-exposed rats | / | / | (155) |
| RP11-397D12.4, AC007403.1, and ERICH1-AS1 | Biomarker | NSCLC cells | Blood | / | (156) |
| SOX2-OT | Biomarker | LUSC cells | Blood | / | (157) |
| / | Changes microenvironment | A549 cells | Culture media | Mesenchymal stem cells | (122) |
| HOTAIR | Promotes cell proliferation, migration, and invasion | Lung cancer cells | Blood | A549 and H1299 | (138) |
| MSTRG.292666.16 | Promotes osimertinib resistance | NSCLC cells, H1975 cells | Blood | H1975 cells | (148) |
| MRPL23-AS1 | Creates a premetastatic microenvironment | SACC cells | Culture medium | HPMECs | (139) |
| UCA1 | Promotes gefitinib resistance | NSCLC cells, HCC827, PC9 | Blood, culture media | HCC827, PC9 | (149) |
| UFC1 | Promotes cell proliferation, migration, and invasion | NSCLC cells | Blood, culture media | A549, H1299 | (158) |
“/” represent not explicit or mentioned; NSCLC, non-small cell lung cancer; LUSC, lung squamous cell carcinoma; SACC, salivary adenoid cystic carcinoma; HCC827/HCC4006/H1975/A549/H1299/PC9, lung cancer cell lines; HPMECs, human pulmonary microvascular endothelial cells.