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. 2020 Sep 23;14:568930. doi: 10.3389/fnins.2020.568930

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Copyright © 2020 Diotel, Lübke, Strähle and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type of divisions of neural stem/progenitor cells and injury-induced proliferation in the telencephalon of adult zebrafish. Left panel: Symmetric gliogenic division (A) in which one dividing RGC provides two new RGCs. A RGC can also divide asymmetrically (B), self-renew and generate a non-glial progenitor (neuroblast). Another possible type of division is the symmetric non-gliogenic division (C) in which one RGC provides two non-glial progenitors. Finally, direct conversion of a RGC into a neuron can also occur (D). The non-glial progenitors can give rise to new neurons through direct conversion (Dc) or indirect conversion (Ic). Right panel: Injury-induced proliferation following traumatic injury in the brain of adult zebrafish (E). In the intact hemisphere (right part), most RGCs are quiescent (type 1) and some are proliferating (type 2). There are also a number of non-glial progenitors in the pallium. Five days after stab wound injury (left part), RGCs actively divide and generate numerous non-glial progenitors (type 3) that will provide new neurons to replace the damaged and dying ones.