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. 2020 Sep 23;14:568930. doi: 10.3389/fnins.2020.568930

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Copyright © 2020 Diotel, Lübke, Strähle and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notch signaling pathway in zebrafish and mouse. Upon interaction between the Notch receptor and its ligands Jagged/Delta, and through several subsequent cleavage steps the NICD is released and translocates to the nucleus. In the nucleus, the NICD, together with Rbpj, activates the expression of the downstream genes Hes (mouse) and her (zebrafish). The Hes/Her proteins bind as homodimers to the promoter of proneural genes to inhibit neuronal fate. Additionally, the dimer can bind to its own promoter, resulting in a negative auto-regulation. bHLH, basic helix-loop-helix; Her, human epidermal growth factor receptor; Hes, Hairy/enhancer of split; NEXT, Notch extracellular truncation; NICD, Notch intracellular domain; Rbpj, Recombining binding protein suppressor of hairless.