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. 2020 Sep 23;14:568930. doi: 10.3389/fnins.2020.568930

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Copyright © 2020 Diotel, Lübke, Strähle and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of Hes1 and Ascl1 controls NSC fate. When BMP and Notch signaling are active, the negative autoregulation of Hes1 is repressed and its expression is constantly high, leading to quiescent NSCs. The negative autoregulatory effect of Hes1 is high when BMP signaling is not active, causing Hes1 and Ascl1 to oscillate. Through this oscillation the NSCs are activated and proliferating. In the case of inactive Notch signaling, the repression of Hes1 on Ascl1 is abolished and the NSCs develop into neuroblasts. Ascl; achaete-scute like.