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. 2020 Sep 23;14:568930. doi: 10.3389/fnins.2020.568930

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Copyright © 2020 Diotel, Lübke, Strähle and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMP and Notch signaling in quiescent RGCs/NSCs. Notch signaling activates gene transcription of Hes in mouse and its zebrafish ortholog her. The Hes/Her proteins form a homodimer which can bind to its own promoter and therefore block its own transcription in a negative feedback loop. BMP signaling activates the transcription of its downstream effector id1. The Id1 protein forms a complex with Hes/Her which inhibits the negative regulatory feedback loop of Hes/Her. BRE, BMP responsive element.