Table 4.
HLA-B*5801 and allopurinol induced drug reaction with eosinophilia and systemic symptoms (DRESS).
| Article | Population | Description | Sensitivity | Specificity | PPV | NPV | Incidenceii,iii | NNG | Frequency carriers in population (%) |
|---|---|---|---|---|---|---|---|---|---|
| Kang et al. (2011) | Korea | 21 DIHS cases + 57 controls | 0.952 | 0.895 | 0.0045 | 1.0000 | 0.0005 | 2100 | 11.8 (South Korea pop 10) (McCabe et al., 2020) |
| Gonçalo et al. (2013) | Portugal | 19 DRESS cases + 23 controls | 0.632 | 0.957 | 0.0072 | 0.9998 | 0.0005 | 3167 | 4.0 (Portugal Center) (McCabe et al., 2020) |
| Cao et al. (2012) | Southern Han Chinese | 3 DRESS cases + 63 tolerant controls + 572 population controls | 1 | 0.889 | 0.0045 | 1 | 0.0005 | 2000 | 14.0 (Cao et al., 2012) |
| Chung et al. (2015) | Taiwan | 22 DRESS cases + 138 controls | 1 | 0.826 | 0.0029 | 1 | 0.0005 | 2000 | 20.0 (Taiwan Han Chinese) (McCabe et al., 2020) |
| Ng et al. (2016) | Taiwan | 60 DRESS cases + 285 controls | 0.917 | 0.821 | 0.0026 | 0.9999 | 0.0005 | 2182 | 20.0 (Taiwan Han Chinese) (McCabe et al., 2020) |
| Sukasem et al. (2016) | Thailand | 6 DRESS cases + 100 tolerant controls +1095 population controls | 1 | 0.960 | 0.0124 | 1 | 0.0005 | 2000 | 10.1 (Sukasem et al., 2016) |
| Saksit et al. (2017) | Thailand | 19 DRESS cases + 182 controls | 1 | 0.885 | 0.0043 | 1 | 0.0005 | 2000 | 14.8 (Thailand) (McCabe et al., 2020) |