Table 9.

HLA-A*3101 and carbamazine induced Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).

Article	Population	Description	Sensitivity	Specificity	PPV	NPV	Incidence	NNG	Frequency carriers in population (%)
Amstutz et al. (2013)	Canada	42 cases (9 SJS/TEN, 6 HSS, 26 MPE, 1 AGEP) + 92 controls	0	0.967	0	0.9999	0.00005	–	No data available of Canadians or North Americans of mixed ethnicity.
Hsiao et al. (2014)	Han Chinese from Taiwan	194 cases (51 MPE, 112 SJS/TEN, 8 other) + 152 controls (investigates associations)	0.018	0.967	0.0014	0.9974	0.0025	22400	5.5 (Taiwan Han Chinese) (McCabe et al., 2020)
Ozeki et al. (2011)	Japan	77 cADR cases (36 DIHS, 6 SJS/TEN, 35 other) + 420 controls	0.833	0.871	0.0160	0.9995	0.0025	480	16.1 (Japan pop 16) (McCabe et al., 2020)
Kim et al. (2011)	Korea	24 SCAR cases (7 SJS, 17 HSS) + 50 tolerant controls + 485 population controls	0.429	0.86	0.0076	0.9983	0.0025	933	10.3 (Kim et al., 2011)
Khor et al. (2017)	Malaysia	28 SJS/TEN cases + 227 controls	0.107	0.947	0.0051	0.9976	0.0025	3733
	Malaysia Chinese	6 cases + 106 controls	0	0.972	0	0.9974	0.0025	–	2.6 (Malaysia Peninsular Chinese) (McCabe et al., 2020)
	Malaysia Indian	6 cases + 57 controls	0.500	0.912	0.0141	0.9986	0.0025	800	4.1 (Malaysia Peninsular Indian) (McCabe et al., 2020)
	Malaysia Malaysian	16 cases + 64 controls	0	0.938	0	0.9973	0.0025	–	0.8 (Malaysia Peninsular Malay) (McCabe et al., 2020)
Ihtisham et al. (2019)	North India	35 cases (27 MPE/6 SJS-TEN/2 DRESS) +70 controls	0	0.957	0	0.9974	0.0025	–	3.8 (India North pop 2) (McCabe et al., 2020)
Genin et al. (2014)	European	20 SJS/TEN cases, 10 DRESS cases + 257 tolerant controls + 8862 population controls	0.150	0.961	0.0002	0.99996	0.00005	133333	4.5 (Genin et al., 2014)
Genin et al. (2014)	Chinese from Taiwan	53 SJS/TEN cases, 10 DRESS cases + 72 tolerant controls + 710 population controls	0.019	0.958	0.0011	0,9974	0.0025	21200	3.7 (Genin et al., 2014)