Alzheimer’s disease |
Rag-5xfAD mice show enhanced Aβ pathology and neuroinflammation (Marsh et al., 2016). |
AB-specific Th2 cells promote neurological recovery (Cao et al., 2009). |
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IFN-y producing Th1 cells enhance microglial activation and Aβ deposition (McQuillan et al., 2010; Browne et al., 2013). |
IL-17 depletion enhances neural precursor cell expression and synaptic transmission (Liu et al., 2014). |
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Depletion of Tregs in mice accelerates AD-related cognitive dysfunction (Baek et al., 2016; Dansokho et al., 2016). |
Adoptive transfer of Tregs reduces Aβ deposition and reverses cognitive deficits (Baek et al., 2016). |
Parkinson’s disease |
SCID, Rag1 KO, TCR B KO, CD4 KO but not CD8 KO mice show attenuated dopaminergic cell death (Benner et al., 2008; Brochard et al., 2009; Gonzalez et al., 2013). |
Copolymer 1 immunized T cells administered to MPTP mice limited neuronal loss (Schori et al., 2001; Benner et al., 2004). |
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Adoptive transfer of T cells from mice immunized with α-synuclein exacerbate MTPT (Reynolds et al., 2010). |
Adoptive transfer of activated Tregs to MPTP provides 90% neuronal protection (Reynolds et al., 2007). |
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IL-17 increases cell death in iPSC-derived neurons from PD patients (Sommer et al., 2019). |
GM-CSF administration increases Tregs, limits inflammation and increases neuroprotection (Kosloski et al., 2013; Gendelman et al., 2017; Schutt et al., 2018). |
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Suppression of CD4 T cell infiltration ameliorates PD symptoms (Qin et al., 2016). |
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Amyotrophic lateral sclerosis |
A Th1/Th17 immune response correlates with disease progression and severity (Saresella et al., 2013; Jin et al., 2020). |
Reconstitution with CD4+ T cells in SOD1G93A mice increases neuroprotection (Beers et al., 2008). |
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In the SOD1G93A model, CD8+ T cell ablation leads to a reduction in motor neuron loss (Coque et al., 2019). |
Disease progression reduces Tregs (Beers et al., 2011). |
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A2BG2 glycan is increased in IgG antibodies for SOD1G93A mice, increasing neuronal cytotoxicity and death (Edri-Brami et al., 2015). |
Adoptive transfer of activated Tregs to SOD1G93A mice delays motor function loss and enhances survival (Banerjee et al., 2008). |