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. 2020 Sep 23;11:575772. doi: 10.3389/fphar.2020.575772

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Copyright © 2020 Huang, He, Liang, Wang, Li, Yang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of water extract of Veratrilla baillonii (WVBF) on non-alcoholic fatty liver disease (NAFLD) lipid, oxidative stress, and inflammation of free fatty acids (FFA)-induced cell. (A) Effect of WVBF on the expression of PPARα (a), SREBP-1c (b), FASN (c), ACC (d), Nrf2 (e), NF-ĸB (f), and TNF-α (g) messenger RNA (mRNA). (B) Protein expression of PPARα, SREBP-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and Nrf2 in FFA-induced LO2 cell was detected by western blot. (C) Effect of WVBF on the expression of Nrf2, ACC, FASN, SREBP-1c, and PPARα protein. n =3 (n, the number of experiment), (^## P < 0.01, ^### P < 0.001, vs. control group; ^* P < 0.05, ^** P < 0.01, and ^*** P < 0.001 vs. FFA group).