Table 3.
Top five KEGG pathway enrichment results.
| Category | Term | Count | % | p-value | Genes | FDR |
|---|---|---|---|---|---|---|
| Upregulated IRGs | ||||||
| KEGG_PATHWAY | Cytokine–cytokine receptor interaction | 28 | 5.405405405 | 2.94E−13 | CCL1, IL21R, CXCL9, TNFRSF8, CXCL6, CXCL11, IL7R, IL10, CXCL10, CCL23, CCL21, IL10RA, CSF2RB, IL1B, CSF1R, IL2RA, TNFRSF13B, CCL19, CCL18, TNFSF8, CCR8, CCL13, CCL14, TNFSF13B, CCR5, CCR4, CXCL13, CCR2 | 3.53E−10 |
| KEGG_PATHWAY | Chemokine signaling pathway | 19 | 3.667953668 | 3.51E−08 | CCL1, PIK3CG, ITK, CXCL9, CCL19, CXCL6, CXCL11, CCL18, CXCL10, CCR8, DOCK2, CCL13, CCL23, CCL14, CCR5, CCL21, CXCL13, CCR4, CCR2 | 4.22E−05 |
| KEGG_PATHWAY | Cell adhesion molecules (CAMs) | 15 | 2.895752896 | 1.03E−06 | PTPRC, CADM3, SELL, ICAM3, ITGAM, PDCD1LG2, HLA-DQA1, CD86, CD80, ICOS, CD22, CD4, CD226, SPN, CD28 | 0.00123743 |
| KEGG_PATHWAY | B cell receptor signaling pathway | 9 | 1.737451737 | 7.44E−05 | PIK3CG, CD19, CR2, FCGR2B, CD22, PIK3AP1, CD79B, CD79A, BTK | 0.089383945 |
| KEGG_PATHWAY | Phagosome | 12 | 2.316602317 | 2.37E−04 | MRC1, MARCO, MSR1, FCGR2B, OLR1, FCGR2C, FCGR1A, CD209, TLR4, FCGR3A, ITGAM, HLA-DQA1 | 0.284714595 |
| Downregulated IRGs | ||||||
| KEGG_PATHWAY | Arachidonic acid metabolism | 4 | 5 | 0.002057483 | AKR1C3, GPX2, CBR1, PLA2G10 | 2.102810979 |
| KEGG_PATHWAY | Metabolic pathways | 13 | 16.25 | 0.002420062 | ETNPPL, DDC, ODC1, PLA2G10, OGDHL, HAL, HGD, TAT, AKR1C3, CBR1, HMGCS2, ENO3, NAT8L | 2.469211516 |
| KEGG_PATHWAY | Tyrosine metabolism | 3 | 3.75 | 0.009368241 | DDC, HGD, TAT | 9.255598588 |
| KEGG_PATHWAY | Metabolism of xenobiotics by cytochrome P450 | 3 | 3.75 | 0.038441569 | AKR1C2, CBR1, AKR1C1 | 33.26837318 |
| KEGG_PATHWAY | Phenylalanine metabolism | 2 | 2.5 | 0.069378576 | DDC, TAT | 52.38108893 |