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Defective autophagy in VSMCs increases femoral artery sensitivity to depolarization. Absolute (A) and relative (C) concentration-response curves of contractions elicited by K+ in femoral artery segments of Atg7+/+ SM22α-Cre+ (+/+) and Atg7F/F SM22α-Cre+ (F/F) mice and fitted maximal force and EC50 values (B,D). (n = 5–7) Two-way ANOVA with sidak post hoc test (A,C) and independent sample t-test (B,D). *p < 0.05, **p < 0.01.
