FIGURE 3.

Defective autophagy in VSMCs increases PE mediated phasic contractions in femoral artery segments. IP₃ mediated transient contractions of Atg7^+/+ SM22α-Cre⁺ (+/+) and Atg7^F/F SM22α-Cre⁺ (F/F) femoral artery segments elicited by 1 μM PE in 0Ca²⁺ conditions (A) and area under the curve (AUC) (B). The double exponential fit of the phasic contraction is shown by the dotted lines, whereas the full lines represent the mean data. Some of the data points are shown with SEM. (n = 7) Two-way ANOVA with sidak post hoc test (A) and independent sample t-test (B). *p < 0.05, **p < 0.01.