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. 2020 Sep 23;11:548943. doi: 10.3389/fphys.2020.548943

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Copyright © 2020 De Munck, De Moudt, Roth, De Meyer, Martinet and Fransen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Defective autophagy in VSMCs increases the sensitivity of femoral artery segments to exogenous NO. Relative concentration-response curves of relaxations elicited by DEANO of Atg7^+/+ SM22α-Cre⁺ (+/+) and Atg7^F/F SM22α-Cre⁺ (F/F) femoral artery segments (A), fitted IC50 (B) and maximal relaxation values (C). (n = 5–6) Two-way ANOVA with sidak post hoc test (A) and independent sample t-test (B,C). *p < 0.05.