. 2020 Oct 6;10:16594. doi: 10.1038/s41598-020-73803-9

Table 3.

Subgroup analysis within MacTel severity 3.

Variable		Inner retinal cavity			Clustered HF at foveola
		Only IR cavity	With other findings	P value*	Present	Absent	P value*
		(N = 50)	(N = 61)	P value*	(N = 19)	(N = 31)	P value*
LogMAR VA	Mean (SE)^a	0.187 (0.030)	0.308 (0.031)	0.005	0.106 (0.030)	0.229 (0.033)	0.006
LogMAR VA	N^b	50	61	0.005	19	31	0.006
FP score^c	Mean (SE)	1.06 (0.17)	1.61 (0.22)	0.034	0.68 (0.17)	1.07 (0.21)	0.154
FP score^c	N	49	58	0.034	19	30	0.154
CBR score^c	Mean (SE)	2.55 (0.63)	3.67 (0.353)	0.012	1.25 (0.18)	3.50 (0.35)	< 0.001
CBR score^c	N	6	13	0.012	3	3	< 0.001
FAF score^c	Mean (SE)	1.61 (0.24)	2.27 (0.24)	0.039	1.06 (0.22)	1.74 (0.29)	0.062
FAF score^c	N	41	48	0.039	18	23	0.062
Early FAG score^c	Mean (SE)	1.63 (0.23)	2.34 (0.17)	0.010	1.43 (0.268)	1.83 (0.297)	0.322
Early FAG score^c	N	44	56	0.010	15	27	0.322
Late FAG score^c	Mean (SE)	1.85 (0.22)	2.67 (0.20)	0.003	1.44 (0.32)	1.98 (0.32)	0.198
Late FAG score^c	N	44	56	0.003	15	27	0.198

CBR confocal blue light reflectance, FAF fundus autofluorescence, FAG fluorescein angiography, FP fundus photo, HF hyperreflective foci, SE standard error, VA visual acuity.

*P values are by generalized linear models and the generalized estimation equation method to account for correlation between eyes.

^aData are expressed as estimated marginal mean (standard errors). Each estimated mean was shown to account for correlation between eyes using generalized linear models and the generalized estimation equation method.

^bThe number of eyes that had gradable images for analysis. Some images are missing or ungradable for each image modality and expressed the number of eyes that included for analysis.

^cThe score was the sum of the affected ETDRS subfields of each image modality.