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. 2020 Oct 6;6:50. doi: 10.1038/s41523-020-00191-8

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© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The breast tissue biopsies from women either susceptible to cancer (Susc) or matched healthy controls (HC) were collected from the upper-outer quadrant of the breast (either right or left). Hematoxylin and eosin staining of susceptible and healthy breast tissues showed the lack of any detectable histological breast abnormality at the time of donation. Images at ×40 magnification are shown. Scale bar: 200 µm. b Laser microdissection microscopy was used to isolate the epithelial, stroma, and adipose tissue compartments separately from each of the 23 fresh-frozen biopsies. c Expression of markers specific for the epithelium (E-Cadherin, CDH1, and pan-Keratins (KRTs)), stroma (fibroblast activation protein, FAP, and desmin, DES), adipose tissue (adiponectin, ADIPOQ, and lipoprotein lipase, LPL) was obtained from the transcriptome profiling. Each marker was highly expressed in the specific microdissected tissue compartment as compared with the other areas of the breast (P < 0.0001), thus indicating sample purity.