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. 2020 Oct 6;6:50. doi: 10.1038/s41523-020-00191-8

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© The Author(s) 2020, corrected publication 2024

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Fig. 3 — a Hierarchical clustering heatmaps of the differentiated transcripts in the microdissected breast epithelium, stroma, and adipose tissue between susceptible (red line) and healthy control (blue line). The epithelium and adipose tissue show a higher number of upregulated genes as compared with the stromal compartment. b Gene ontology enrichment (PANTHER_GO) and c pathway analyses (IPA v01-06) of upregulated and downregulated genes. d Master regulator analysis (IPA v01-06) for the differentially expressed genes between susceptible and healthy control breasts in the three breast tissue compartments. Upregulated molecules in the susceptible as compared with the healthy controls are in red, and the downregulated molecules are in green. Arrows indicate the intermolecular relationship: activation (orange), inhibition (blue), effect not predicted (gray), inconsistency with the state of the downstream molecule (yellow).