Table 4.
List of lipid metabolism-related genes upregulated in the microdissected susceptible breast epithelium.
| Gene symbol | Gene name | FC | P value |
|---|---|---|---|
| Lipolysis | |||
| PLIN1 | Perilipin 1 | 3.9 | 3.1E-04 |
| LIPE | Lipase E, hormone-sensitive type | 2.2 | 4.4E-04 |
| PLIN4 | Perilipin 4 | 2.5 | 2.7E-03 |
| LPL | Lipoprotein lipase | 1.8 | 1.6E-02 |
| Transport/uptake | |||
| AQP7 | Aquaporin 7 | 2.5 | 1.2E-05 |
| RBP4 | Retinol-binding protein 4 | 3.7 | 3.0E-04 |
| CD36 | CD36 molecule | 1.7 | 4.3E-03 |
| FABP4 | Fatty acid-binding protein 4 | 2.2 | 5.5E-03 |
| APOB | Apolipoprotein B | 3.0 | 9.7E-03 |
| Synthesis | |||
| AKR1C1 | Aldo–keto reductase 1 C1 | 4.3 | 1.2E-05 |
| ACSM1 | Acyl-CoA synthetase medium-chain 1 | 13.6 | 1.7E-05 |
| GPD1 | Glycerol-3-phosphate dehydrogenase 1 | 2.9 | 3.2E-03 |
| SDS | Serine dehydratase | 2.4 | 5.8E-03 |
| PCCA | Propionyl-CoA carboxylase alpha subunit | 1.3 | 9.0E-03 |
| AKR1C3 | Aldo–keto reductase 1 C3 | 1.7 | 1.3E-02 |
| ELOVL7 | ELOVL fatty acid elongase 7 | 2.6 | 1.3E-02 |
| DHRS12 | Dehydrogenase/reductase 12 | 1.3 | 2.2E-02 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 1.8 | 2.5E-02 |
| ACSS3 | Acyl-CoA synthetase short-chain 3 | 1.5 | 3.2E-02 |
| ACACB | Acetyl-CoA carboxylase beta | 1.3 | 3.7E-02 |
| PPARG | Peroxisome proliferator-activated receptor γ | 1.4 | 4.9E-02 |
| FASN | Fatty acid synthase | 2.0 | 5.0E-02 |
| SCD | Stearoyl-CoA desaturase | 2.0 | 7.2E-02 |
| Lipid metabolism regulation | |||
| ADIPOQ | Adiponectin, C1Q, and collagen domain containing | 3.8 | 1.9E-03 |
| LEP | Leptin | 3.8 | 1.3E-02 |
FC fold change.