Table 4.

mRNA levels of studied genes in the population who received Bacillus Calmette–Guerin (BCG) therapy and association with response.

GENES	Responsea n = 13	No responseb n = 15	p value**
PVRL4	122.90 [63.41–262.88]*	137.25 [33.37–638.75]*	0.53
MDM4	0.88 [0.50–1.24]	0.98 [0.71–1.63]	0.066
NFE2L2	1.87 [1.06–2.90]	1.59 [0.60–4.13]	0.77
PPARG	14.15 [5.91–18.73]	12.51 [2.26–17.67]	0.17
PIK3CA	1.81 [0.33–9.81]	0.62 [0.37–1.31]	0.39
PRKCI	4.07 [0.00–6.96]	3.71 [0.80–11.16]	0.7
FGFR3	27.94 [9.09–104.57]	73.47 [5.25–143.15]	0.037
TACC3	4.98 [1.36–9.32]	3.86 [1.39–12.08]	0.39
FBXW7	0.88 [0.60–1.26]	1.03 [0.64–1.74]	0.44
PAIP1	0.79 [0.63–1.96]	0.85 [0.10–1.09]	0.98
E2F3	2.13 [1.36–2.74]	2.17 [0.81–4.14]	0.73
SOX4	6.39 [3.53–11.76]	6.40 [1.91–12.88]	0.34
EGFR	1.34 [0.45–3.08]	0.92 [0.33–2.67]	0.35
ZNF703	1.09 [0.42–2.18]	1.27 [0.08–3.44]	0.39
PABPC1	2.21 [0.99–4.16]	2.02 [1.38–3.54]	0.27
YWHAZ	1.36 [1.14–3.69]	1.37 [0.68–2.48]	0.61
MYC	0.85 [0.60–1.82]	0.74 [0.30–2.36]	0.56
RXRA	2.04 [1.59–5.79]	1.96 [1.16–4.81]	0.98
GDI2	2.43 [1.50–3.19]	2.12 [0.92–3.10]	0.10
Ki67	8.21 [37.92–72.23]	29.36 [1.80–63.41]	0.27
CCND1	3.40 [0.43–17.88]	2.76 [1.27–10.71]	0.45
HRAS	1.29 [0.77–1.91]	1.30 [0.63–6.00]	0.60
ERBB3	20.49 [11.83–38.13]	19.20 [7.06–43.90]	0.98
MDM2	1.93 [1.17–3.67]	2.06 [0.94–6.08]	0.50
FRS2	0.65 [0.52–0.93]	0.71 [0.48–1.22]	0.24
ERBB2	7.91 [5.15–45.03]	6.43 [2.88–12.50]	0.20
CCNE1	3.78 [2.02–9.72]	3.78 [1.08–27.69]	0.85
ERCC2	1.48 [1.28–2.57]	1.78 [0.80–2.69]	0.45
BCL2L1	1.46 [0.76–1.72]	1.42 [0.75–2.35]	0.98

^aNo recurrence or late recurrence (≥ 24 months).

^bBCG-refractory or early recurrence (< 24 months).

*Median mRNA value [range].

**Kruskall Wallis H test.

Bold value is statistically significant (p < 0.05).