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. 2020 Oct 6;10(10):96. doi: 10.1038/s41408-020-00361-8

Table 3.

Overall survival analysis.

Variable Alive (%) 12-month OS (%) Median OS p-value (univariate) p-value (multiv.)
Overall 50/71(70.4) 68.6 NR
Age
<70 years 38/51 (78.5) 73.0 NR 0.241
>70 years 12/20 (60.0) 58.3 NR
Sex
Male 27/39 (69.2) 68.0 NR 0.877
Female 23/32 (71.9) 69.3 NR
WBC
<30 × 109/L 43/60 (71.7) 70.0 NR 0.490
>30 × 109/L 7/11 (63.6) 62.3 NR
Marrow blasts
<30% 17/22 (77.3) 76.7 NR 0.371
>30% 33/49 (67.3) 64.9 NR
Previous HMA
No 16/54 (70.4) 68.9 NR 0.945
Yes 15/17 (70.6) 69.1 NR
NPM1
Wild type 43/63 (68.3) 66.6 NR 0.162
Mutated 5/5 (100) 100 NR
FLT3-ITD
Negative 45/64 (70.3) 68.3 NR 0.570
Positive 3/5 (60.0) 60.0 NR
TP53
Wild type 20/24 (83.3) 83.1 NR 0.081 0.570
Mutated 7/13 (53.8) 51.9 NR
Karyotype
Fav./Int. 31/39 (79.5) 78.6 NR 0.049 0.051
Poor 19/32 (59.4) 56.6 NR
Therapy related
No 35/49 (71.4) 68.7 NR 0.717
Yes 15/22 (68.2) 68.2 NR
ELN 2017
Low/Int. 26/32 (88.9) 79.9 NR 0.073 0.071
High 24/39 (64.7) 59.5 NR
MRD TP1
Negative 11/15 (73.3) 71.1 NR 0.414
Positive 21/25 (84.0) 84.0 NR