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. 2020 Oct 6;10:16546. doi: 10.1038/s41598-020-73312-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representation of FUS procedure, system, and software. (a) The RK50 stereotactic system from FUS Instruments used during our experiments. (b) A schematic of the experimental set-up used in this study. Of note, a 27-gauge tail vein catheter was used during our procedure for delivery of the bubble infusion. (c) Skull landmarks lambda and bregma are identified with the stereotactic system after an incision has been made in the mouse’s shaved scalp. (d) A Python-based software uses a mouse brain atlas registered to the identified skull landmarks to carry out a sonication treatment plan of multiple sequential points. (e) A hydrophone returns an acoustic signal that is transformed by the software into a visual representation of the acoustic spectra from which the area under the curve (AUC) is calculated. The authors thank April Gill for creating the drawing in (b) and kindly providing it to us for publication.