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. 2020 Oct 6;10:16546. doi: 10.1038/s41598-020-73312-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images showing heterogeneity in brain parenchyma as indicated by T2-weighted MR images. T2-weighted images with corresponding inset of post-contrast T1-weighted images showing differences in T2 heterogeneity at some FUS treated locations. Case examples shown in images correspond to specific points on the plot of acoustic pressure versus bubble dosage influx (lower left, connected to images by dotted lines) where T2 heterogeneity was observed. WL and WW of images have been adjusted as stated in “Methods” section.