Table 2.
Oxidative stress parameters in blood in rats orally treated with ADT. Rats (n = 18) were orally administered 1 mg/kg (b.w.) vehicle (saline) or ADT once a day for three weeks. At one-week interval biomarkers of oxidative stress were measured in blood (n = 3 for each group). PSSG values in RBC membranes are expressed as pmoles/mg Hb. ∗∗p < 0.01 vs. vehicle group.
| Parameter | 1 week | 2 weeks | 3 weeks | |||
|---|---|---|---|---|---|---|
| Vehicle group | ADT∗ group | Vehicle group | ADT group | Vehicle group | ADT group | |
| Plasma PTI | 0.369 ± 0.023 | 0.271 ± 0.017∗∗ | 0.397 ± 0.024 | 0.248 ± 0.060∗∗ | 0.347 ± 0.010 | 0.240 ± 0.038∗∗ |
| RBCs GSH/GSSG | 389 ± 21 | 435 ± 27∗∗ | 358 ± 14 | 430 ± 36∗∗ | 392 ± 23 | 405 ± 13∗∗ |
| Membrane PSSG | 10.8 ± 0.8 | 4.6 ± 0.74∗∗ | 9.3 ± 0.12 | 3.6 ± 0.59∗∗ | 14.3 ± 1.1 | 4.4 ± 0.2∗∗ |
| Plasma MDA (nM) | 54.6 ± 2.1 | 20.5 ± 0.8∗∗ | 64.7 ± 4.2 | 22.8 ± 1.4∗∗ | 51.3 ± 7.0 | 22.5 ± 1.2∗∗ |
Abbreviations: ADT: anethole dithiolethione; PTI: protein thiolation index; PSSG: S-thiolated proteins; MDA: malonyldialdehyde.