Table 3.
Activity of γ-glutamyltranspeptidase in several organs of rats treated with ADT. Rats (n = 18) were orally administered 1 mg/kg (b.w.) vehicle (saline) or ADT once a day for three weeks. At one-week intervals, the activity of γ-glutamyltranspeptidase (γ-GT) was measured in organ homogenates (n = 3 for each group). Data are expressed as mU/mg protein. ∗p < 0.05 vs. vehicle group, ∗∗p < 0.01 vs. vehicle group.
| Organ | 1 week | 2 weeks | 3 weeks | |||
|---|---|---|---|---|---|---|
| Vehicle group | ADT group | Vehicle group | ADT group | Vehicle group | ADT group | |
| Liver | 1.42 ± 0.03† | 0.692 ± 0.087∗ | 1.50 ± 0.11 | 0.523 ± 0.098∗∗ | 1.65 ± 0.078 | 0.413 ± 0.055∗∗ |
| Kidney | 2840 ± 195 | 1850 ± 109∗∗ | 3010 ± 224 | 1865 ± 86∗∗ | 2964 ± 340 | 1698 ± 101∗∗ |
| Heart | 2.20 ± 0.11 | 1.52 ± 0.07∗∗ | 2.00 ± 0.16 | 1.56 ± 0.13∗∗ | 1.89 ± 0.11 | 1.43 ± 0.02∗∗ |
| Lung | 8.25 ± 0.54 | 4.45 ± 0.50∗∗ | 7.86 ± 0.55 | 5.12 ± 0.34∗∗ | 7.97 ± 0.30 | 5.10 ± 0.26∗∗ |
| Brain | 2.29 ± 0.14 | 1.68 ± 0.21∗∗ | 2.12 ± 0.18 | 1.68 ± 0.14∗∗ | 2.06 ± 0.15 | 1.46 ± 0.27∗∗ |
| Testis | 2.03 ± 0.13 | 2.41 ± 0.18 | 1.86 ± 0.07 | 2.24 ± 0.20 | 2.67 ± 0.35 | 1.37 ± 0.09∗∗ |
Abbreviations: ADT: anethole dithiolethione.