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Freehand segmentation of IDH-wild LGG. (a) The ROI-1 (entire tumor ROI) delineated on an ADC map, (b) the corresponding ADC histogram of the ROI-1, (c) the ROI-2 (tumor ROI excluding cystic and necrotic portions) delineated on an ADC map, and (d) the corresponding ADC histogram of the second segmentation (color should be used for this figure).
