Figure 6.

CircLPAR1 in exosomes induced osteogenic differentiation of recipient homotypic DPSC through downregulation of miR-31. (a) ALP assay of miR-31-inhibited DPSCs and circLPAR1-overexpressed DPSCs cultured for 14 days. (b) Alizarin red staining of miR-31-inhibited groups and circLPAR1-overexpressed group cultured for 21 days. (c) The expression level of important osteogenic differentiation-related genes (SATB2, RUNX2, col-1, and OCN) in miR-31-inhibited group, circLPAR1 overexpressed, and EX7 treated for 14 days. DPSCs were detected by Western blot assay.