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. 2020 Sep 23;14:706. doi: 10.3389/fnins.2020.00706

TABLE 3.

Differences in physical and mental comorbidities between bothersome and non-bothersome tinnitus.

Non-bothersome tinnitus
Bothersome tinnitus
Variable Frequency (count data) Adjusted residuals Frequency (count data) Adjusted residuals
Female participants

n = 3894 n = 392
Hypertension 5.7% (223) −2.3 8.7% (34) 2.3
Hyperlipidemia∗∗ 2.5% (97) −3.0 5.1% (20) 3.0
Cardiovascular disease∗∗∗ 4.2% (165) −4.4 9.2% (36) 4.4
Asthma 12.5% (485) 0.0 12.5% (49) 0.0
Diabetes 0.5% (19) −1.4 1.0% (4) 1.4
Thyroid disease∗∗∗ 5.8% (226) −3.8 10.7% (42) 3.8
n = 3891 n = 392
Chronic shoulder pain∗∗∗ 7.2% (282) −4.8 14.0% (55) 4.8
Osteoarthritis∗∗∗ 5.4% (212) −4.4 11.0% (43) 4.4
Rheumatoid arthritis 0.8% (30) 0.0 0.8% (3) 0.0
Systemic lupus erythematosus 0.1% (5) 0.7 0.0% (0) −0.7
Migraine 19.2% (749) −1.2 21.7% (85) 1.2
Ménière’s disease 0.2% (8) −1.2 0.5% (2) 1.2
Epilepsy∗∗ 0.7% (26) −2.9 2.0% (8) 2.9
Multiple sclerosis 0.1% (5) 0.7 0.0% (0) −0.7
Fibromyalgia∗∗∗ 1.3% (50) −4.3 4.1% (16) 4.3
Burnout∗∗∗ 12.1% (470) −4.3 19.6% (77) 4.3
Depression∗∗ 25.0% (972) −2.9 31.6% (124) 2.9
Bipolar disease 0.7% (29) −1.6 1.5% (6) 1.6
Anxiety syndrome 12.3% (478) −1.6 15.1% (59) 1.6
Panic 13.9% (542) −0.3 14.5% (57) 0.3
Agoraphobia 0.7% (28) −1.2 1.3% (5) 1.2
Social anxiety 3.7% (143) −2.4 6.1% (24) 2.4
Obsessive-compulsive disorder 2.5% (97) −0.7 3.1% (12) 0.7
Posttraumatic stress disorder 2.2% (84) −1.8 3.6% (14) 1.8

Male participants

n = 2992 n = 303
Hypertension∗∗ 5.9% (176) −3.2 10.6% (32) 3.2
Hyperlipidemia∗∗ 3.8% (114) −3.4 7.9% (24) 3.4
Cardiovascular disease 3.7% (112) −1.9 5.9% (18) 1.9
Asthma 9.7% (289) −0.9 11.2% (34) 0.9
Diabetes 0.7% (22) 1.5 0.0% (0) −1.5
Thyroid disease 0.8% (25) −1.4 1.7% (5) 1.4
n = 2991 n = 303
Chronic shoulder pain∗∗∗ 2.8% (85) −5.0 8.3% (25) 5.0
Osteoarthritis∗∗ 3.7% (111) −3.0 7.3% (22) 3.0
Rheumatoid arthritis 0.3% (9) −1.0 0.7% (2) 1.0
Systemic lupus erythematosus 0.0% (0) 0.0 0.0% (0) 0.0
Migraine 8.9% (267) −0.8 10.2% (31) 0.8
Ménière’s disease∗∗∗ 0.2% (5) −4.5 1.7% (5) 4.5
Epilepsy 0.7% (21) 0.8 0.3% (1) −0.8
Multiple sclerosis 0.2% (5) 0.7 0.0% (0) −0.7
Fibromyalgia 0.1% (4) 0.6 0.0% (0) −0.6
Burnout 7.6% (227) −1.0 9.2% (28) 1.0
Depression∗∗ 14.5% (433) −2.8 20.5% (62) 2.8
Bipolar disease 0.8% (23) 0.9 0.3% (1) −0.9

Non-bothersome tinnitus
Bothersome tinnitus
Variable Frequency (count data) Adjusted residuals Frequency (count data) Adjusted residuals

Female participants

Anxiety syndrome∗∗∗ 7.0% (210) −4.1 13.5% (41) 4.1
Panic∗∗ 7.4% (221) −3.6 13.2% (40) 3.6
Agoraphobia 0.3% (10) −0.9 0.7% (2) 0.9
Social anxiety∗∗ 2.9% (88) −3.4 6.6% (20) 3.4
Obsessive-compulsive disorder 1.4% (43) −1.2 2.3% (7) 1.2
Posttraumatic stress disorder 0.8% (23) −1.6 1.7% (5) 1.6

Factors in bold font indicate significant differences in frequencies (adjusted residuals ≥1.96 or ≤−1.96). ∗∗∗p < 0.001, ∗∗p < 0.01, p < 0.05.