Table 1: Prospective Longitudinal Studies of Incident Hypertension in Patients with Obstructive Sleep Apnoea.

Authors	Study	Type of Study	Patients (n)	Follow-up(Years)	Comparisons		Associations
						OR [95% CI]	Adjusted OR [95% CI]
Peppard et al. 2000[15]	WSCS	Prospective	709	4	AHI <5 (versus 0) AHI 5–14.9 AHI ≥15	1.42 [1.13–1.78] 2.03 [1.29–3.17] 2.89 [1.46–5.64]
O’Connor et al. 2009[16]	SHHS	Prospective	2,470	5.2	AHI 15–29.9 (versus 0–4.9) AHI ≥30	1.54 [1.12–2.11]* 2.19 [1.39–3.44]*	1.12 [0.80–1.56]† 1.51 [0.91–2.46]†
Cano-Pumarega et al. 2011[17]	VSC	Prospective	1,180	7.5	RDI 3–6.9 (versus 0–2.9) RDI 7–13.9 RDI ≥14	1.49 [1.09–2.03] 1.84 [1.30–2.61] 2.61 [1.75–3.89]	1.09 [0.78–1.52]‡ 0.94 [0.64–1.39]‡ 1.00 [0.63–1.57]‡
Guillot et al. 2013[18]	SYNAPSE	Prospective	372	3	AHI ≥30	2.21 [1.43–3.43]	1.77 [1.11–2.80]§
Marín et al. 2012[19]	ZSCS	Prospective	1,889	12.2	Ineligible for CPAP (n=462) Declined CPAP (n=195) Non-adherent to CPAP (n=98) Treated with CPAP (n=824)	1.63 [1.25–2.12]||,¶ 2.89 [2.18–3.84]||,¶ 2.70 [1.90–3.83]||,¶ 1.47 [1.24–1.88]||,¶	1.46 [1.12–1.91]||,** 2.54 [1.90–3.39]||,** 2.20 [1.90–3.39]||,** 1.01 [0.78–1.31]||,**
Appleton et al. 2016[20]	MAILES	Prospective	391	4.6	AHI ≥20 AHI ≥30	– –	1.95 [1.04–3.63]†† 2.24 [1.04–4.81]††

*Adjusted for age, sex, race and time since baseline. †Adjusted for age, sex, race, time since baseline and BMI. ‡Adjusted for age, sex and BMI. §Adjusted for sex, obesity, type 2 diabetes and dyslipidaemia. ||HRs for new-onset hypertension (per 100 person-years). ¶Adjusted for AHI, age and sex. **Adjusted for AHI, age, sex, SBP/DBP and BMI. ††Adjusted for age, waist circumference, smoking, alcohol, AHI_NREM and weight gain over the follow-up period. AHI = apnoea-hypopnoea index; CPAP = continuous positive airway pressure; NREM = non-rapid eye movement; OSA = obstructive sleep apnoea; RDI = respiratory disturbance index; SBP/DBP = systolic/diastolic blood pressure.