Table 2.
HPV association in oropharyngeal tumours with clinicopathological characteristics.
| Variable | HPV-negative | HPV-positive | p-value |
|---|---|---|---|
| N (%) | N (%) | ||
| 63 (82.9) | 13 (17.1) | ||
| Age (years ± SD) | 57.08 (7.11) | 58.46 (6.40) | 0.562*1 |
| Sex | |||
| Man | 55 (84.6) | 10 (15.4) | 0.388*2 |
| Woman | 8 (72.7) | 3 (27.3) | |
| TNM | |||
| III | 5 (71.4) | 2 (28.6) | 0.166*3 |
| IVA | 45 (80.4) | 11 (19.6) | |
| IVB | 13 (100.0) | 0 (0.0) | |
| Grade | |||
| Well differentiated | 10 (83.3) | 2 (16.7) | 0.016*3 |
| Moderately differentiated | 36 (94.7) | 2 (5.3) | |
| Poorly differentiated | 16 (64.0) | 9 (36.0) | |
| Histology | |||
| Keratinizing | 36 (90.0) | 4 (10.0) | 0.177*3 |
| Non-keratinizing | 26 (74.3) | 9 (25.7) | |
| Undifferentiated | 1 (100.0) | 0 (0.0) | |
| Mutational status | |||
| Non-mutated | 15 (78.9) | 4 (21.1) | 0.726*2 |
| Mutated | 48 (84.2) | 9 (15.8) | |
| TP53 mutated | |||
| Non-mutated | 18 (66.7) | 9 (33.3) | 0.009*2 |
| Mutated | 45 (91.8) | 4 (8.2) | |
| PIK3CA mutated | |||
| Non-mutated | 57 (85.1) | 10 (14.9) | 0.178*2 |
| Mutated | 6 (66.7) | 3 (33.3) | |
TNM classification system stands for tumour, node and metastasis.
HPV status based on p16 + IHC could only be measured in 76 (84.4%) out of the 90 oropharyngeal tumour samples.
SD standard deviation, Unk unknown.
*1Mann-Whitney U test.
*2Fisher’s exact test.
*3Chi-square test.