Table 1. Anti-cancer drugs benefitted by liposome .
Drug | Lipid Component | Interpretation | Special feature | Ref. |
Raloxifene hydrochloride | DSPC: Cholesterol, diethylene triamine penta acetic acid | Raloxifene loaded liposomal formulation provided effective uterine targeting as compared to non-liposomal drug. | Gamma scintigraphy studies depicted selective uptake of radiolabeled RLH. | 69 |
Raloxifene |
Dipalmitoyl phosph-atidylcholine, dioctyl phosphatidyl choline and calcium chloride. Dimethyl-β-cyclodextrin and sodium taurocholate |
Raloxifene dimethyl-β-CD cochleate formulations were found to be successful in reducing breast tumors. Further matrix metalloproteinase-2 (MMP-2) enzyme was also found to be inhibited. | MCF-7 cell lines were used to evaluate antitumor activity. | 70 |
Adriamycin |
EPC/Chol 55:45 Chloroform, isopropanol, Water. |
Adriamycin loaded liposome on local administration effectively inhibiting the proliferating cells by inducing apoptosis thereby reducing lymph node metastasis. | Highest apoptotic index of 21.73%. | 71 |
Doxorubicin |
Phosphatidylcholine, and cholesterol |
Doxorubicin-loaded liposomes offered enhanced permeability and retention effect. | Passive targeting at cancer cells. | 72 |