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. 2020 Aug 9;10(4):524–541. doi: 10.34172/apb.2020.064

Table 1. Anti-cancer drugs benefitted by liposome .

Drug Lipid Component Interpretation Special feature Ref.
Raloxifene hydrochloride DSPC: Cholesterol, diethylene triamine penta acetic acid Raloxifene loaded liposomal formulation provided effective uterine targeting as compared to non-liposomal drug. Gamma scintigraphy studies depicted selective uptake of radiolabeled RLH. 69
Raloxifene Dipalmitoyl phosph-atidylcholine, dioctyl phosphatidyl choline and calcium chloride. Dimethyl-β-cyclodextrin and sodium
taurocholate
Raloxifene dimethyl-β-CD cochleate formulations were found to be successful in reducing breast tumors. Further matrix metalloproteinase-2 (MMP-2) enzyme was also found to be inhibited. MCF-7 cell lines were used to evaluate antitumor activity. 70
Adriamycin EPC/Chol 55:45 Chloroform, isopropanol,
Water.
Adriamycin loaded liposome on local administration effectively inhibiting the proliferating cells by inducing apoptosis thereby reducing lymph node metastasis. Highest apoptotic index of 21.73%. 71
Doxorubicin Phosphatidylcholine, and cholesterol
Doxorubicin-loaded liposomes offered enhanced permeability and retention effect. Passive targeting at cancer cells. 72