Table 4. List of anti-cancer drugs formulated as NLCs .

Drug	Lipid vehicle	Interpretation and remark	Ref.
Docetaxel	Soy lecithin, glyceryl monostearate, and fatty acids	Prepared DTX-NLC (murine melanoma treatment) accounts for lower toxicity in therapeutics dose and selective cytotoxicity to A549 cells through apoptosis.	119
Docetaxel oleate	Poloxamer F68, oleic acid, and Glyceryl monostearate	Prepared prodrug NLC of Docetaxel exhibited improved membrane permeability in in-situ single pass intestinal perfusion and 4.04 fold increase in bioavailability	120
Biochanin A	Glycerol monostearate, medium chain triglyceride, soya lecithin, and Tween 80*	Biochanin loaded NLC exhibited higher AUC values with prolonged in-vitro residence time	121
Tamoxifen citrate	Poloxamer 188, glyceryl monostearate, Labrafil WL 2609 BL, Tween 20*, and Tween 80*	Similar cytotoxic activity was observed both on human (MCF-7) and mice (4T1) breast cancer cell lines form Tamoxifen and Tamoxifen-NLC	122
Tamoxifen citrate	Glyceryl monostearate, Labrafil WL 2609 BL,Tween20*, Tween 80*, Poloxamer 188*	Tamoxifen loaded NLC exhibited 2.71 and 7.10 fold increment in bioavailability and T1/2 respectively, also measurable amount was detected in mesenteric lymph node.	123
Etoposide	Glyceryl monostearate, soybean oil, soya lecithin	Etoposide loaded-DSPE-NLC was highly cytotoxic to human epithelial-like lung cell carcinoma cells, and even relative bioavailability was 3.5 fold to Etoposide-suspension	124

*Emulsifier.