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. 2020 Aug 9;10(4):524–541. doi: 10.34172/apb.2020.064

Table 7. List of anti-cancer agents benefitted by SNEDDs .

Drug Lipid Components Interpretation Ref.
Etoposide Oleoylmacrogol-6-glycerides,
Gelucire 44/14, Peceol, Transcutol**
P, Plurol Oleique and Labrasol*
The formulation showed better transportation of etoposide across the Caco-2 cell lines and higher cytotoxicity than the Etosid® and free drug against A549 human epithelial lung carcinoma cell lines 176
Docetaxel Capryol 90, Labrasol*, and Transcutol HP** 17% higher oral bioavailability for D-SNEDDs as compared to 2.6 % for Docetaxel solution, with high anti-tumor efficacy and reduced toxicity. 177
Tamoxifen
citrate
Maisine 35-1, Capryol 90, Cremophor RH40*, propylene glycol** Higher drug release from SNEDDs as compared to Tamoxifen citrate suspension. 178
Docetaxel Maisine 35-1and Capmul MCM with Tween 80* and Transcutol-HP** Self Nano Emulsifying Lipidic Nano-micelles System (SNELS) Formulation enriched with PUFA (Long Chain Glyceride) exhibited better dissolution, enhanced p-gp inhibition and reduced pre-systemic metabolism as depicted from in vivo pharmacokinetic studies, better permeability and absorption was also reflected from ex-vivo permeation andin situ perfusion studies. Moreover LCG based formulation were highly targeted to lymphatic system as compared to MCG (medium-chain fatty acid glyceride) 179

*Emulsifier, **Co-emulsifier.