Table 2. Overview of various injectable scaffolds uses in MI80 .
Scaffolds (Natural and synthetic) | Material form | Delivery factor |
Alginate | Hydrogel | HGF, IGF-1; PDGF-BB, VEGF-A |
Chitosan | Hydrogel | bFGF; FGF-2 |
Collagen | Hydrogel | N/A |
Decellularized myocardial ECM | Hydrogel | N/A |
Decellularized pericardial ECM | Hydrogel | bFGF; HGF |
Dextran | Microparticles | HGF |
Fibrin | Hydrogel | bFGF |
Gelatin | Microspheres | bFGF; IGF-1, VEGF |
Hyaluronic acid | Hydrogel | rTIMP-3 |
Keratin | Hydrogel | N/A |
Matrigel | Hydrogel | N/A |
PEG based | Hydrogel | VEGF; HGF, VEGF; HGF, IGF-1; EPO |
PLGA based | Microparticles, nanoparticles | NRG-1, FGF-1; VEGF; IGF-1 |
PNIPAAm based | Hydrogel | bFGF |
UPy | Hydrogel | HGF, IGF-1 |
bFGF: basic fibroblast growth factor; FGF: fibroblast growth factor; HGF: hepatocyte growth factor; IGF: insulin-like growth factor; MI: myocardial infarction; PDGF-BB: platelet-derived growth factor BB; PEG: polyethylene glycol; PLGA: poly(lactic-co-glycolic acid); PNIPAAm: poly(N-isopropylacrylamide); rTIMP: recombinant tissue inhibitor of matrix metalloproteinase-3; SDF-1: stromal cell-derived factor; UPy: ureidopyrimidinone; VEGF: vascular endothelial growth factor.