Table 2.
Cohort 1 (Early Effect): Cardiovascular Biomarkers
| Chol (mmol/l) | HDL-C (mmol/l) | LDL-C (mmol/l) | TGs (mmol/l) | Gluc (mmol/l) | HbA1C (mmol/mol) | vWF:Ag (%) | t-PA (ng/ml) | PAI-1 (ng/ml) | hs-CRP (mg/l) | ICAM-1 (ng/ml) | hs-TNI (pg/ml) | Log Urine ACR (mg/l) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Surveillance (n = 10) | ||||||||||||||
| BL | 5.2 ± 0.3 | 1.2 ± 0.1 | 3.3 ± 0.3 | 1.2 ± 0.2 | 4.9 ± 0.1 | 34.7 ± 1.1 | 44.3 ± 4.8 | 11.9 ± 2.5 | 111.2 ± 4.3 | 2.1 ± 1.0 | 408.1 ± 37.4 | 0.24 ± 0.16 | −0.18 ± 0.10 | |
| 1–2 weeks | 5.1 ± 0.3 | 1.3 ± 0.1 | 3.2 ± 0.2 | 1.1 ± 0.2 | 4.9 ± 0.1 | 34.2 ± 0.9 | 42.8 ± 5.2 | 13.5 ± 3.1 | 116.7 ± 3.3 | 2.1 ± 0.7 | 389.3 ± 47.7 | 0.19 ± 0.19 | −0.30 ± 0.05 | |
| 6 weeks | 5.0 ± 0.3 | 1.2 ± 0.1 | 3.2 ± 0.2 | 1.2 ± 0.1 | 5.0 ± 0.2 | 33.4 ± 0.8 | 45.9 ± 5.3 | 12.1 ± 2.4 | 113.0 ± 3.1 | 1.7 ± 0.7 | 387.6 ± 39.1 | 0.47 ± 0.35 | −0.25 ± 0.06 | |
| 3 months | 4.7 ± 0.3 | 1.2 ± 0.1 | 3.0 ± 0.2 | 1.1 ± 0.1 | 5.1 ± 0.2 | 33.8 ± 0.7 | 43.2 ± 4.1 | 12.8 ± 2.5 | 111.3 ± 5.3 | 2.0 ± 0.8 | 417.4 ± 32.1 | 0.13 ± 0.13 | −0.30 ± 0.04 | |
| 6 months | 4.7 ± 0.3 | 1.2 ± 0.1 | 2.9 ± 0.2 | 1.2 ± 0.2 | 5.1 ± 0.2 | 33.8 ± 0.5 | 48.2 ± 4.6 | 13.7 ± 2.6 | 110.9 ± 3.9 | 3.4 ± 1.8 | 454.9 ± 58.9 | 0.15 ± 0.11 | −0.18 ± 0.07 | |
| 9 months | 4.8 ± 0.4 | 1.2 ± 0.1 | 3.0 ± 0.2 | 1.2 ± 0.2 | 5.0 ± 0.2 | 35.0 ± 1.0 | 51.2 ± 6.7 | 16.7 ± 2.4 | 101.8 ± 6.2 | 1.8 ± 0.8 | 460.4 ± 23.4 | 0.31 ± 0.21 | −0.22 ± 0.07 | |
| 1–2 cycles of BEP (low-intensity cisplatin) (n = 7) | ||||||||||||||
| BL | 5.1 ± 0.5 | 1.3 ± 0.1 | 3.4 ± 0.4 | 1.1 ± 0.2 | 5.1 ± 0.2 | 33.1 ± 1.0 | 38.4 ± 3.4 | 9.0 ± 1.2 | 105.6 ± 8.0 | 3.8 ± 1.5 | 353.6 ± 37.5 | 0.19 ± 0.19 | −0.23 ± 0.08 | |
| 24 h | 4.9 ± 0.4 | 1.3 ± 0.1 | 3.3 ± 0.4 | 0.7 ± 0.1 | 6.9 ± 0.2∗ | 33.7 ± 0.9 | 43.1 ± 1.6 | 6.1 ± 0.9 | 108.9 ± 6.7 | 2.2 ± 0.5 | 355.1 ± 32.6 | 0.43 ± 0.29 | 0.13 ± 0.04† | |
| 6 weeks | 5.8 ± 0.8 | 1.2 ± 0.1 | 3.8 ± 0.7 | 2.1 ± 0.3 | 5.1 ± 0.2 | 35.6 ± 1.1 | 52.8 ± 1.9 | 7.2 ± 0.9 | 109.5 ± 2.8 | 4.4 ± 1.9 | 437.8 ± 57.7 | 1.21 ± 0.50 | −0.21 ± 0.05 | |
| 3 months | 5.1 ± 0.8 | 1.2 ± 0.1 | 3.4 ± 0.7 | 1.5 ± 0.3 | 5.0 ± 0.2 | 30.0 ± 0.7 | 44.3 ± 6.0 | 10.5 ± 2.4 | 111.1 ± 3.7 | 3.4 ± 1.3 | 436.9 ± 49.7 | 0.24 ± 0.24 | −0.21 ± 0.15 | |
| 6 months | 5.2 ± 0.5 | 1.2 ± 0.1 | 3.4 ± 0.4 | 1.4 ± 0.3 | 4.9 ± 0.1 | 35.0 ± 1.1 | 55.8 ± 8.4 | 15.4 ± 3.6 | 105.0 ± 5.9 | 1.6 ± 0.5 | 452.7 ± 41.3 | 0.94 ± 0.51 | −0.29 ± 0.10 | |
| 9 months | 4.9 ± 0.4 | 1.2 ± 0.1 | 3.2 ± 0.3 | 1.2 ± 0.1 | 5.2 ± 0.2 | 32.7 ± 0.9 | 55.0 ± 8.2 | 13.4 ± 3.2 | 101.7 ± 8.0 | 4.0 ± 2.1 | 425.6 ± 45.0 | 0.27 ± 0.27 | −0.09 ± 0.18 | |
| 3–4 cycles of BEP (high-intensity cisplatin) (n = 10) | ||||||||||||||
| BL | 5.5 ± 0.2 | 1.8 ± 0.4 | 3.5 ± 0.2 | 1.9 ± 0.5 | 5.0 ± 0.2 | 35.5 ± 1.2 | 45.2 ± 2.8 | 13.4 ± 1.3 | 114.4 ± 2.8 | 2.7 ± 1.5 | 411.1 ± 28.9 | 0.83 ± 0.55 | −0.14 ± 0.05† | |
| 24 h | 5.7 ± 0.3 | 1.8 ± 0.4 | 4.0 ± 0.3 | 1.1 ± 0.2 | 6.6 ± 0.2∗ | 35.3 ± 1.3 | 42.4 ± 2.7 | 13.5 ± 1.3 | 110.7 ± 2.9 | 1.4 ± 0.5 | 382.2 ± 32.1 | 0.12 ± 0.12 | 0.20 ± 0.07† | |
| 6 weeks | 7.2 ± 0.5† | 2.3 ± 0.6 | 4.7 ± 0.5 | 2.6 ± 0.5 | 5.2 ± 0.3 | 41.8 ± 2.0∗ | 62.4 ± 5.4† | 14.6 ± 2.7 | 115.5 ± 3.7 | 3.1 ± 1.6 | 460.8 ± 43.1 | 1.39 ± 0.63 | 0.20 ± 0.16 | |
| 3 months | 6.7 ± 0.4 | 1.8 ± 0.4 | 4.2 ± 0.4 | 3.1 ± 0.7 | 5.0 ± 0.1 | 29.1 ± 1.7∗ | 48.9 ± 3.8 | 15.1 ± 2.0 | 104.5 ± 3.5 | 3.7 ± 1.9 | 495.2 ± 20.5 | 1.41 ± 0.70 | −0.23 ± 0.08 | |
| 6 months | 6.2 ± 0.4 | 1.7 ± 0.4 | 3.8 ± 0.3 | 2.9 ± 0.5 | 5.1 ± 0.2 | 37.8 ± 0.9 | 47.7 ± 4.9 | 16.1 ± 2.6 | 108.0 ± 3.2 | 1.5 ± 0.4 | 392.2 ± 62.4 | 0.47 ± 0.24 | −0.28 ± 0.07 | |
| 9 months | 6.1 ± 0.3 | 1.8 ± 0.5 | 4.1 ± 0.3 | 2.4 ± 0.3 | 5.1 ± 0.2 | 33.8 ± 0.9 | 48.2 ± 3.0 | 15.3 ± 2.5 | 110.4 ± 3.9 | 3.4 ± 1.5 | 440.8 ± 40.1 | 1.22 ± 0.40 | −0.17 ± 0.08 | |
Values are mean ± SEM.
BL = baseline; Chol = cholesterol; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; gluc = glucose; hs-CRP = high-sensitivity C-reactive protein; hs-TNI = high-sensitivity troponin I; ICAM = intracellular adhesion molecule; PAI = plasminogen activator inhibitor; TG = triglyceride; t-PA = tissue plasminogen activator; vWF:Ag = von Willebrand factor antigen.
∗
p < 0.001;
†
p < 0.05.