Table 1.
Cell phenotype in the intestinal lamina propria during the early phase of T. spiralis infection
| No. of positive cells/VCU | ||||||
|---|---|---|---|---|---|---|
| CD4 | CD25 | CD8α | CD8β | TCRαβ | TCRγδ | |
| Control | 75.2 ± 12.5a, c | 61.6 ± 5.9c | 162.4 ± 23.5c | 129.8 ± 26.1c, e, g | 177.2 ± 39.4c | 151.4 ± 20.7c |
| 2 dpi | 95.2 ± 2.3b | 90.2 ± 8.2d | 215.2 ± 55.5 | 254.6 ± 29.4d | 223.8 ± 63.9d | 241.4 ± 63.9d |
| 4 dpi | 161.4 ± 18.5d | 153.0 ± 18.4d | 215.0 ± 29.7d | 176.2 ± 12.9f | 236.6 ± 32.1d | 208.2 ± 16.4d |
| 6 dpi | 185.0 ± 20.8d | 150.4 ± 6.5d | 87.0 ± 37.8d | 87.2 ± 25.5d | 79.4 ± 6.3d | 79.2 ± 9.9d |
| 13 dpi | 263.0 ± 36.8d | 175.0 ± 12.9d | 193.0 ± 24.8 | 183.2 ± 21.1h | 141.2 ± 12.3 | 155.4 ± 5.9 |
Notes: Results are expressed as mean of number (no.) of positive cells/VCU ± SD (n = 5/dpi and n = 5, control) at a 400× magnification. Data were analysed by the negative binomial distribution followed by Tukey’s multiple comparisons test (MASS and multcomp packages, respectively). Significant differences between infected and control rats: P < 0.05: a vs b; P < 0.001: d vs c; P = 0.008: e vs f; P = 0.014: g vs h