Table 1.
Characteristics of studies included in the meta-analysis of anti-Saccharomyces cerevisiae antibodies in Behçet’s disease, its main differential diagnoses, and healthy controls
| Year and author | Countries | Type | Type of article | Design | Sample size | Methods | Brands of experimental materials | Cut-off (U/mL) |
Diagnostic criteria | |||||
| BD | GIBD | CD | UC | iTB | HC | |||||||||
| 2018 Zhang et al10 | China | IgG; IgA; IgG/IgA; IgG+IgA | Original article | Case–control | / | 71 | 171 | 208 | 57 | 70 | ELISA | Inova Diagnostic | 25 | NR |
| 2017 Zhang et al9 | China | IgG; IgA; IgG/IgA; IgG+IgA | Original article | Retrospective study | / | 34 | 128 | 140 | 31 | / | ELISA | Euroimmun, Luebeck | 20 | NR |
| 2011 Vaiopoulos et al34 | Greece | IgG; IgA | Original article | Case–control | 58 | 4† | / | / | / | 56 | ELISA | Inova Diagnostic | NR | 1990 ISG criteria |
| 2010 Kocazeybek. et al8 | Turkey | IgG/IgA | Conference Abstract | Case–control | / | 13 | 63 | 102 | 10 | 165 | IIF | Euroimmun, Luebeck | NR | NR |
| 2006 Choi et al35 | Korea | IgG | Original article | Case–control | 30* | 106 | / | / | / | 45 | IIF | Euroimmun, Luebeck | 1:1000 | 1987 Japan criteria |
| 2005 Fresko et al21 | Turkey | IgG; IgA; IgG/IgA; IgG+IgA | Original article | Case–control | 85 | 8 | 24 | 25 | / | 21 | ELISA | Inova Diagnostic | 28 for IgG; 25 for IgA |
1990 ISG criteria |
| 2005 Rhee et al36 | Korea | IgG | Original article | Case–control | / | 16 | / | / | / | 4 | ELISA | Inova Diagnostic | 25 | 1987 Japan criteria |
| 2002 Krause et al16 | Israel | IgG; IgA; IgG/IgA; IgG+IgA | Original article | Case–control | 27* | / | / | / | / | 10 | ELISA | Inova Diagnostic | 25 | 1990 ISG criteria |
| 2002 Kim et al37 | Korea | IgG+IgA+IgM | Original article | Case–control | / | 36 | 85 | 77 | 14 | 20 | ELISA | Plate: Sigma Chemical antibody: Biosoft | ROC curve | 1987 Japan criteria |
*All without gastrointestinal manifestations.
†Lack of corresponding data.
/, no sample; BD, Behçet’s disease; CD, Crohn's disease; GIBD, gastrointestinal Behçet’s disease; HC, healthy control; IIF, indirect immunofluorescence assay; 1990 ISG criteria, the 1990 criteria of Behçet’s Disease International Study Group; iTB, intestinal tuberculosis; 1987 Japan criteria, the 1987 criteria by the Behçet’s Disease Research Committee of Japan; NR, not reported; UCs, ulcerative colitis.