Table 2.
Association between the presence of ASCA and BD (without gastrointestinal symptom)/GIBD and other intestinal diseases
| Subgroup | Antibody | Number of studies | Diagnostic OR (95% CI) |
Significance test (p) |
| BD vs HC | ASCA-IgG | 4 | 1.00 (0.28 to 3.53) | 0.997 |
| ASCA-IgA | 2 | 2.50 (0.63 to 9.96) | 0.194 | |
| ASCA-IgG+IgA | 2 | 1.06 (0.17 to 6.78) | 0.954 | |
| ASCA-IgG/IgA | 2 | 2.88 (0.62 to 13.44) | 0.179 | |
| GIBD vs HC | ASCA-IgG | 3 | 5.50 (2.58 to 11.55) | 0.000 |
| ASCA-IgA | 2 | 2.65 (1.18 to 5.96) | 0.018 | |
| ASCA-IgG+IgA | 2 | 5.36 (1.40 to 20.45) | 0.014 | |
| ASCA-IgG/IgA | 3 | 2.90 (1.47 to 5.74) | 0.002 | |
| GIBD vs CD | ASCA-IgG | 3 | 0.48 (0.28 to 0.83) | 0.009 |
| ASCA-IgA | 3 | 0.91 (0.56 to 1.46) | 0.685 | |
| ASCA-IgG+IgA | 3 | 0.58 (0.30 to 1.11) | 0.100 | |
| ASCA-IgG/IgA | 4 | 0.57 (0.28 to 1.15) | 0.117 | |
| GIBD vs UC | ASCA-IgG | 3 | 1.78 (0.98 to 3.22) | 0.057 |
| ASCA-IgA | 3 | 2.13 (1.30 to 3.50) | 0.003 | |
| ASCA-IgG+IgA | 3 | 2.19 (1.03 to 4.66) | 0.042 | |
| ASCA-IgG/IgA | 4 | 2.03 (1.30 to 3.17) | 0.002 | |
| GIBD vs iTB | ASCA-IgG | 2 | 1.08 (0.50 to 2.32) | 0.854 |
| ASCA-IgA | 2 | 1.51 (0.71 to 3.22) | 0.290 | |
| ASCA-IgG +IgA | 2 | 1.02 (0.40 to 2.62) | 0.972 | |
| ASCA-IgG/IgA | 3 | 1.05 (0.58 to 1.87) | 0.883 |
ASCA, anti-Saccharomyces cerevisiae antibodies; BD, Behçet’s disease without gastrointestinal symptom; CD, Crohn's disease; GIBD, gastrointestinal Behçet’s disease; HC, healthy control; iTB, intestinal tuberculosis; UC, ulcerative colitis.