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Genetic risk for Alzheimer’s disease. Mutations in APP, PSEN1, and PSEN2 that cause younger-onset AD (YOAD; also known as “familial AD”) are rare with the vast majority of genetic risk for late onset (LOAD; also known as “sporadic AD”) arising through common variants in multiple genes that each increase risk but which individually are not causative. Figure modified from Karch and Goate (2015).
