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. 2020 Oct 6;8(1):e001537. doi: 10.1136/bmjdrc-2020-001537

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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HR for developing diabetes in those who took at least some study metformin during DPPOS (n=652)*. HRs and their 95% CIs from a Cox Proportional Hazards model for time to diabetes measured from DPPOS baseline. All variables listed in the figure are covariates included in a multivariate model. Age, marital status, educational level, employment status, and income level were all measured at DPP baseline. The follow-up SF-36 and number of concomitant medications variables are averages during follow-up. Cumulative metformin adherence is calculated as the cumulative per cent of visits (up to and including each collection time point) at which a participant took 80% or more of their prescribed study metformin. *Includes only participants whose diagnosis of diabetes, or censoring, occurred on or after August 1, 2002 (the official start date of DPPOS) were included in this analysis. There was a total of 216 participants from this study who developed diabetes prior to the start of DPPOS. Depression scores, anxiety scores, and number of concomitant medications were included in the models as logged values, so estimates of OR for these covariates are expressed per 1-unit log increase. DPP, Diabetes Prevention Program; DPPOS, DPP Outcomes Study; SF-36, Short Form-36.